Top US diplomat Condoleezza Rice will make a landmark trip to Libya this week, the first by a US Secretary of State in more than half a century, the State Department announced.

Her trip is a tangible sign of warming US-Libya relations, which first began to thaw when Tripoli gave up its weapons of mass destruction program in 2003.

"It is a historic stop," said State Department spokesman Sean McCormack. "It certainly does mark a new chapter in US-Libya relations."    

Rice, who is expected to meet Libyan leader Muammar Gaddafi on her September 4-7 trip, also will visit Maghreb nations Tunisia, Algeria and Morocco and stop over in Lisbon, Portugal, before returning to Washington on Sunday.

US Secretary of State John Foster Dulles was the last top US diplomat to visit Tripoli and made the trip in May 1953, before Rice was born.

"If you think about this expanse of time and what has happened in that period of time -- we have had a man land on the moon, the Internet, the Berlin Wall fall and we have had 10 US presidents," McCormack said.

Rice could sign a trade and investment framework deal during her visit and US officials said both sides were discussing a number of other agreements, including education, security, political and cultural, to try and expand ties.

But how quickly ties improve will depend on whether Libya implements a deal signed last month between the two countries to establish a humanitarian fund to resolve compensation cases involving victims of US and Libyan bombings.

"The development of a relationship to the level we would like is inhibited until we get this agreement implemented," Assistant Secretary of State David Welch, who led negotiations with Libya on the compensation cases, told Reuters.

Welch said money had not yet been put in a humanitarian fund to pay out the victims, but he was optimistic it would happen soon and Rice would press Libya on this issue.

"I expect the Libyans to fulfill the agreement," Welch told Reuters. "The motivation will be very strong for them to move forward," he added.

US victims covered include those who died in the 1988 bombing of Pan Am Flight 103 over Lockerbie, Scotland, which killed 270 people, and the 1986 attack on a Berlin disco that killed three people and wounded 229.

It also covers Libyans killed in 1986 when US planes bombed Tripoli and Benghazi. Forty people died.

Anticipating an angry response from some US families of victims of Libyan attacks, Welch and other senior officials briefed relatives before the official announcement.

Another sticking point with Libya has been on human rights concerns and Welch said Rice would raise these although he declined to provide details of any specific cases. - Reuters